Study design

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The study builds on the APCAPS prospective cohort investigating risk factors for cardio-metabolic disease over the life course conducted by investigators in India (Public Health Foundation of India, National Institute of Nutrition) and the UK (LSHTM, University of Bristol).

APCAPS includes over 4000 participants, residing in 29 villages southeast of Hyderabad, Telangana.

www.apcaps.lshtm.ac.uk

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Work Packages

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1- Particle exposure assessment

This workpackage includes

  • Outdoor PM2.5 and black carbon monitoring across the ACPAPS villages through two saturation monitoring campaigns covering two seasons.
  • 24h-integrated personal gravimetric PM2.5measurements on a 10% sample of APCAPS participants (n=400) in two seasons.
  • Development of models to predict exposure for epidemiological analyses.

2- Identifying influential exposure microenvironments

This workpackage includes

  • A panel study on a subset of participants (n=40) with six repeated 24h measurements of continuous PM2.5 personal exposure, GPS location, and time activity data collected using a wearable camera.
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3- Epidemiological analysis

This workpackage includes

  • Quantifying the relationship between several metrics of exposure generated for the full cohort in workpackage 1 with a measure of atherosclerosis (carotid intima media thickness) as well as arterial stiffness.
  • Analyses to explore whether the relationship between combustion particles and cardiovascular risk is different depending on the source (e.g. solid fuel combustion, traffic exhaust).